Open AccessEFFECT OF MELATONIN IN POST-STROKE RECOVERY
Author(s) -
SARA SHREEN,
NABILA NOOREEN,
UMRA ZAHID,
AIMEN MALEEHA,
AYESHA SAMREEN,
MOHAMMED ZOHEB
Publication year - 2022
Publication title -
asian journal of pharmaceutical and clinical research
Language(s) - English
Resource type - Journals
eISSN - 2455-3891
pISSN - 0974-2441
DOI - 10.22159/ajpcr.2022.v15i4.43466
Subject(s) - melatonin , observational study , stroke (engine) , medicine , neuroprotection , modified rankin scale , neurology , adverse effect , physical therapy , anesthesia , ischemic stroke , psychiatry , mechanical engineering , ischemia , engineering
Objective: Stroke is the second main cause of death worldwide. Recovery from a stroke differs from person to person. Melatonin is a neuroprotective agent with low adverse effects. The limitation of melatonin studies on human and other clinical bases made us keen to took up this research work to explore its full potential as a neuroprotective agent. The purpose of this research was to evaluate the effect of melatonin in stroke recovery inpatients.Methods: This was a present prospective observational study carried out at the Department of Neurology of tertiary care hospital over 6 months. The patient data were collected through history interview and from the case sheets. Continuous variables were presented as the minimum, maximum, median, mean, and standard error of the mean (SEM). Categorical variables were presented as frequencies and percentages.Results: A total of 80 patients were included in this study based on inclusion criteria. A significant difference was not found in the age and gender between the two study groups. There is a statistically significant difference in the percentage of improvement of modified Rankin Scale (mRS), Communication Disability Scale (CDS), and Cognitive Assessment of Stroke Patients (CASP) scores between the study groups.Conclusion: Our study concluded that patients received melatonin along with first-line treatment which has shown better efficacy in treating post-recovery stroke patients when compared with patients received first-line treatment alone. Melatonin served as an excellent neuroprotectant in patients of acute ischemic stroke with improvement in the motor, speech, and cognitive functions.