Open AccessSPLENIC PROTECTIVE EFFECT OF WHITE TURMERIC EXTRACT AGAINST COPPER TOXICITY IN MALE WISTAR RATS
Author(s) -
Linda Chiuman
Publication year - 2021
Publication title -
asian journal of pharmaceutical and clinical research
Language(s) - English
Resource type - Journals
eISSN - 2455-3891
pISSN - 0974-2441
DOI - 10.22159/ajpcr.2021.v14i5.40789
Subject(s) - spleen , histopathology , toxicity , necrosis , inhalation , white blood cell , white pulp , pharmacology , anti inflammatory , medicine , chemistry , pathology , immunology , anesthesia
Objective: This study was aimed to investigate the protective effect of white turmeric against copper splenic toxicity in male Wistar rats.
Methods: This study used 30 rats divided into six groups: Negative groups, positive groups, Ethanol Extract of White Turmeric I-III. After 14 days, all rats were sacrificed by chloroform inhalation, and the spleen was excised and process to histopathology preparation and evaluation.
Results: The result of this study showed that white turmeric acutely protected spleen from the impact of copper by reducing congestion/vasodilatation of the blood vessel (p=0.002), neutrophil infiltration (p<0.05), and lymphoid necrosis (p<0.05). Nevertheless, white turmeric extract may induce chronic inflammation by increasing the number of macrophage cells (p=0.003).
Conclusion: Overall, it can be concluded that the white turmeric extracts acutely protect spleen from the impact of copper.