Open AccessINVESTIGATION OF ANALGESIC, ANTIOXIDANT, AND CYTOTOXIC PROPERTIES OF THE ETHANOLIC EXTRACT OF STREBLUS ASPER (ROOTS)
Author(s) -
Ananta Kumar Das,
Rozina Parul,
Md. Monirul Islam,
Apu Ghosh,
Mohd Alam
Publication year - 2021
Publication title -
asian journal of pharmaceutical and clinical research
Language(s) - English
Resource type - Journals
eISSN - 2455-3891
pISSN - 0974-2441
DOI - 10.22159/ajpcr.2021.v14i5.39520
Subject(s) - chemistry , brine shrimp , antioxidant , traditional medicine , analgesic , cytotoxic t cell , flavonoid , pharmacology , food science , biology , biochemistry , medicine , in vitro
Objective: This study evaluated the analgesic, antioxidant, and cytotoxic effects of ethanolic extract of Streblus asper roots.
Methods: Analgesic activities were carried out using paw licking and writhing tests. The extract was used at doses of 250 and 500 mg/kg per orally in Swiss albino mice of body weight 25–30 g. Antioxidant properties were investigated using 1, 1-diphenyl-1-picrylhydrazyl free-radical scavenging assay, total phenol content, total flavonoid content as well as reducing power capacity. The cytotoxic activity was determined by the Brine Shrimp lethality bioassay.
Results: The ethanolic extract of S. asper roots showed a significant effect in the formalin test (p<0.01). They also exhibit the highest analgesia (p<0.01) in the acetic acid-induced writhing model as well. The extract possessed antioxidant effects in all the models. It possessed a good cytotoxic activity.
Conclusion: The results suggested that S. asper root extract has a suitable analgesic, antioxidant effect as well as significant cytotoxic potential.