Open AccessEVALUATION OF GASTROPROTECTIVE POTENTIAL OF CAJANUS CAJAN SEEDS EXTRACT ON ETHANOL-INDUCED GASTRIC ULCER IN ALBINO RATS
Author(s) -
Nkiruka C. Azubuike,
B. AMARA UDEMBA
Publication year - 2021
Publication title -
asian journal of pharmaceutical and clinical research
Language(s) - English
Resource type - Journals
eISSN - 2455-3891
pISSN - 0974-2441
DOI - 10.22159/ajpcr.2021.v14i12.43268
Subject(s) - cimetidine , cajanus , medicine , stomach , distilled water , traditional medicine , ethanol , gastroenterology , acute toxicity , toxicity , biology , chemistry , biochemistry , chromatography , horticulture
Objective: The present study was undertaken to evaluate the gastroprotective potential of Cajanus cajan seed aqueous extract (CCSE) on experimentally induced gastric ulcer in albino rats.Methods: Preliminary acute toxicity study was conducted to determine the oral median lethal dose (LD50). Twenty (20) male rats divided into 5 groups (A-E) of 4 animals each were used. Group A (normal control) and B (ulcer model) received 10ml/kg distilled water. Groups C, D and E received Cimetidine (100mg/kg b.w intraperitoneally), 250mg/kg and 500mg/kg b.w of CCSE orally respectively, once daily for seven (7) days. On Day 8, gastric ulcers were induced in groups B – E using 80% ethanol (1ml/rat) prior to sacrifice. Ulcer indices were determined on excised stomach tissues prior to further processing for histological examination.Results: The LD50 of CCSE is greater than 5g/kg b.w. Cimetidine and CCSE treatments showed statistically significant decrease (p<0.05) in ulcer indices compared to group B (ulcer model). Histological features revealed noticeable preservation of the gastric mucosa in consistence with the macroscopical findings.Conclusion: The present study revealed that C. cajan seed extract possesses gastroprotective properties against ethanol-induced gastric ulcers.