Open AccessHYDROGEL FORMULATION FROM CALOTROPIS GIGANTEA PLANT EXTRACT AGAINST FOOT ULCER CAUSING BACTERIA IN DIABETES
Author(s) -
Ramachandran Am,
Senthil Prabhu S,
Joseph Devakumar,
J. Rengaramanujam,
Karthik Sundaram S,
R Mahenthiren,
Varsha Tk
Publication year - 2021
Publication title -
asian journal of pharmaceutical and clinical research
Language(s) - English
Resource type - Journals
eISSN - 2455-3891
pISSN - 0974-2441
DOI - 10.22159/ajpcr.2021.v14i11.37147
Subject(s) - bacteria , traditional medicine , diabetic foot ulcer , antibacterial activity , diabetic foot , calotropis procera , medicine , diabetes mellitus , chemistry , biology , endocrinology , genetics
Objective: The objective of present study was to develop hydrogel formulations loaded with Calotropis gigantea leaves extract.Methods: The prepared hydrogel formulations were compliance with their color, odor, homogeneity, pH, and spreadability.Results: As all the formulations were complies with the all parameters and it can be suggest as a Good antibacterial gel. It is evident that, ethanolic extract of Calotropis gigantea showed a maximum inhibitory zone against bacteria associated with foot ulcer.Conclusions: The In vitro studies showed a quantity dependent increase in antibacterial activity against foot ulcer causing bacteria, a contraction which is higher than that produced by the control groups. These contractions were statistically significant (p<0.05), during the study with leave extract against foot ulcer causing bacteria in diabetes.