Open AccessSMOKING CARCINOGENS AND LUNG CANCER – A REVIEW
Author(s) -
S. P. Vinay,
Chandan Dharmashekara,
Ashwini Prasad,
Kollur Shiva Prasad,
Chandrashekar Srinivasa,
Kavitha Gc,
Poojitha B. Sridhara Setty,
Chandan Shivamallu
Publication year - 2021
Publication title -
asian journal of pharmaceutical and clinical research
Language(s) - English
Resource type - Journals
eISSN - 2455-3891
pISSN - 0974-2441
DOI - 10.22159/ajpcr.2021.v14i1.39811
Subject(s) - carcinogen , lung cancer , cancer , malignancy , nicotine , cancer research , chemistry , genetics , biology , medicine , pathology
Smoking ambiguity contributes to a certain revelation regarding the process by which cancer is induced. In the laboratory, carcinogens induce clear lung tumor to lung cancer induction. For instance, carcinogenic chemicals, namely, 4(methyl nitrosomine)-1-(3-pyridyl)-1-butanol, and nitrosonornicotine (NNN) cause tumor malignancy. It is evident from the mechanistic studies that the carcinogens have a stronger tendency to mutate the genes like suppresser gene, a gene that encodes the receptor of the cell surface to the nucleus, thus, giving way to the proliferation of mutation leading to neoplastic cells. In this analysis article, we have discussed molecular mechanics that can cause cancer by nitrosamines such as nicotine-derived nitrosamine ketone and NNN regarding a variety of significant cigarette combustion carcinogens and the effort to introduce a different dimensional approach to the prevention of cancer, by understanding the perspective of various treatments.