Open AccessCOMPARISON OF INSULIN RESISTANCE WITH THE SEVERITY OF METABOLIC SYNDROME
Author(s) -
N BHAGYASHREE,
C RAMASWAMY,
K RAMYA,
M GANESH
Publication year - 2020
Publication title -
asian journal of pharmaceutical and clinical research
Language(s) - English
Resource type - Journals
eISSN - 2455-3891
pISSN - 0974-2441
DOI - 10.22159/ajpcr.2020.v13i9.38444
Subject(s) - insulin resistance , glycated hemoglobin , medicine , metabolic syndrome , insulin , blood sugar , hemoglobin , endocrinology , gastroenterology , significant difference , diabetes mellitus , obesity , type 2 diabetes
Objective: Insulin resistance (IR) means a reduced ability of insulin to stimulate glucose utilization. IR is related to cardiovascular disease (CVD) risk as the IR forms the basis for atherogenesis and acts as a major risk factor for atherosclerotic CVD.
Methods: Total of 195 participants were recruited divided into three groups based on the presence of metabolic abnormalities as control Group I (with <3 components of metabolic syndrome [MS]), MS group as Group II (with any 3 components of MS), and severe MS as Group III (with more than three components of MS).
Results: Results showed that fasting blood sugar (FBS) and glycated hemoglobin showed a significant difference between the groups (p<0.001), whereas fasting insulin and IR were higher in severe MS which showed statistically significant difference (p<0.001) in comparison with control and MS group.
Conclusion: IR is one of the principal factors for the development of MS and further threw light that the increase in the IR level proportionately increases the severity of MS.