Open AccessFORMULATION AND EVALUATION OF NEW MEDICATED CHEWING FOR THE TREATMENT OF NAUSEA AND VOMITING INDUCED BY CHEMOTHERAPY, RADIATION THERAPY, AND POST-OPERATIVE CONDITIONS IN CANCER
Author(s) -
Lall Dipesh,
Shruti Rathor,
Soni Pranay
Publication year - 2020
Publication title -
asian journal of pharmaceutical and clinical research
Language(s) - English
Resource type - Journals
eISSN - 2455-3891
pISSN - 0974-2441
DOI - 10.22159/ajpcr.2020.v13i4.37094
Subject(s) - nausea , vomiting , ondansetron , saliva , bioavailability , drug , medicine , pharmacology , friability , anesthesia , first pass effect
Objective: The objective of the present study was formulation and evaluation of new medicated chewing for the treatment of nausea and vomiting induced by chemotherapy, radiation therapy, and post-operative conditions in cancer using ondansetron hydrochloride as drug candidate.
Methods: The medicated chewing gum of ondansetron hydrochloride (OHC) was prepared by direct compression mold method. Four formulations were selected for study which was showing good physicochemical properties and drug release. Formulations were characterized for physical evaluation, weight variation, stickiness, hardness/plasticity, in vitro drug release, estimation of chewing gum consistency and drug release study in saliva.
Results: All the formulations gave satisfactory results in physical evaluation, weight variation, stickiness, and hardness. The formulation medicated chewing gum II (MCG II) showed best in vitro drug release which is 97% in 30 min and it is also more accepted by the people. Drug release in saliva also indicated that more than 50% drug release occurs within 15 min.
Conclusion: Medicated chewing gum is a cost-effective product and also showed better compliance and increase in bioavailability.