Open AccessFORMULATION AND EVALUATION OF HERBAL OIL-BASED ITRACONAZOLE CREAM FOR FUNGAL INFECTION
Author(s) -
Inder Kumar,
Bhumika Thakur,
Ankita Sharma,
Reena Thakur
Publication year - 2020
Publication title -
asian journal of pharmaceutical and clinical research
Language(s) - English
Resource type - Journals
eISSN - 2455-3891
pISSN - 0974-2441
DOI - 10.22159/ajpcr.2020.v13i11.39172
Subject(s) - itraconazole , bioavailability , olive oil , traditional medicine , tea tree oil , antifungal , medicine , chemistry , mathematics , chromatography , food science , essential oil , pharmacology , dermatology
Objective: The current study was to formulate and to evaluate itraconazole herbal oil-based cream for fungal infection.
Methods: Six herbal oils were used for the formulation of itraconazole creams, namely, mustard oil (MO), olive oil (OO), wheat germ oil (WGO), jojoba oil (JO), tea tree oil (TTO), and combined oil (CO). Creams were formulated by the trituration method. Each herbal oils containing three different formulations of different concentrations of oils.
Results: All the prepared formulation was evaluated successfully. Out of all the formulations from each herbal oils the best two formulations were finalized, that is, MO2 and CO2 which show the greater in vitro diffusion rate among all. Formulation MO2 shows 55.45±0.10% and CO2 showed 59.43±1.18% within 480 min, respectively. Optimized formulations were also compared with the marketed formulation, which results in formulation CO2 as the best formulation among all.
Conclusion: It can be concluded that herbal oil-based cream proved better alternate than oral preparation and improve patient compliance, ease of administration, local bioavailability, and better proves for fungal infected patients.