Open AccessTHE RELATIONSHIP BETWEEN BASELINE CD4 T CELLS’ LEVEL AND RECOVERY RATE AFTER INITIATION OF ART IN HIV/AIDS INFECTED AT HOSPITAL FOR TROPICAL DISEASES, VIETNAM
Author(s) -
Tào Gia Phú,
Huynh Thi Hong Nhung
Publication year - 2020
Publication title -
asian journal of pharmaceutical and clinical research
Language(s) - English
Resource type - Journals
eISSN - 2455-3891
pISSN - 0974-2441
DOI - 10.22159/ajpcr.2020.v13i10.38383
Subject(s) - medicine , viral load , cd4 t cell , antiretroviral therapy , outpatient clinic , human immunodeficiency virus (hiv) , pandemic , immunology , baseline (sea) , t cell , covid-19 , disease , biology , immune system , fishery , infectious disease (medical specialty)
Objective: HIV/AIDS pandemic continues to be a public health problem in developing countries. This study aimed to assess the correlation of recovery responses and baseline CD4 T cells’ level in HIV/AIDS adult patients after initiation of antiretroviral therapy (ART) in Vietnam.
Methods: The study was a clinic-based longitudinal study done at an outpatient clinic, Tropical Diseases Hospital, Ho Chi Minh City, Vietnam, from 10/2018 to 8/2019.
Results: Ninety-three patients were provided informed consent to participate in this study. Overall, the mean of CD4 T cell counts was 161.7 cells/μl. In AIDS patients groups, at the baseline mean of T CD4 cell was 65 cells/μl and in the non-AIDS group was 315 cells/μl. The slope of the plotted overall CD4 cell counts increased significantly in both two groups and the steepest increases in the first 3 months. After 6 months, patients who were AIDS stages were had a higher viral load in plasma than others, with p<0.005. The changes in CD4 T cell counts were significantly associated with age and occupational status.
Conclusion: The present study found that immunological responses of patients with first-line ART were not related to baseline CD4 T cells’ level. However, low baseline CD4 counts were associated with poor virologic suppression.