ANTI-ULCER ACTIVITY OF HYDROALCOHOLIC EXTRACT OF PIPER BETLE LEAF ON EXPERIMENTAL ANIMALS

Objective: The main objective of this study is to establish the anti-ulcer activity of hydroalcoholic extract of Piper betle leaf on experimental animals based on previously existing aspects such as antioxidant, antihistaminic, and antimicrobial properties of P. betle leaf. Methods: The leaves were collected, shed dried, and extracted by the Soxhlet apparatus using 70% ethanol. The anti-ulcer activity of the extract was evaluated in albino Wistar rats employing pyloric ligation and stress-induced antiulcer models. Ranitidine was served as a standard drug in both the models. The significance of activity was assessed using a one-way analysis of variance followed by Dunnett’s post-parametric test. Results: In the pyloric ligation model, the untreated control has shown 4.3 mEq/l of acidity, whereas the ranitidine-treated standard group shown 2 mEq/l and P. betle has shown 2.5 mEq/l acidity, respectively. In the stress-induced antiulcer model, the activity was more prominent, in the untreated control, there was 26 number of sores present, whereas the standard group showed only one number of ulcer sore, and in the P. betle treated group, there was four number of ulcer sores present. Conclusion: In the present study, P. betle exhibited potent antiulcer potential while compared with the untreated control and the activity is comparable with standard ranitidine. From the above findings, it can correlate the use of betel leaf as a digesting or gastroprotective agent.