Open AccessSynthesis and anti–microbial activity of 1,2,3–triazole tethered nitroguiacol ethers
Author(s) -
Sridhar Rachakonda,
Fatima Naaz,
Intzar Ali,
K.R.S. Prasad,
Venkata Basaveswara Rao Mandava,
Syed Shafi
Publication year - 2019
Publication title -
asian journal of pharmaceutical and clinical research
Language(s) - English
Resource type - Journals
eISSN - 2455-3891
pISSN - 0974-2441
DOI - 10.22159/ajpcr.2019.v12i5.29603
Subject(s) - antimicrobial , broth microdilution , bacteria , chemistry , staphylococcus aureus , pseudomonas aeruginosa , broad spectrum , triazole , microorganism , click chemistry , microbiology and biotechnology , antifungal , gram positive bacteria , minimum inhibitory concentration , combinatorial chemistry , biology , organic chemistry , genetics
Nitro aromatic/nitrophenols have been widely distributed in nature and are mostly isolated from marine microorganisms and had shown a broad spectrum of anti–microbial activities against a wide range of microbial pathogens. The objective of the present work is to Synthesize some new 1,2,3–triazole tethered nitroguiacol ethers and evaluated of their anti–bacterial and anti–fungal activities. A focused library of 1,2,3-triazole tethered nitroguiacol ethers were prepared by employing Cu (I) catalyzed click chemistry reaction and evaluated for their antimicrobial activities by broth microdilution method. Among the tested compounds, compounds 8e, 8f, 8g, and 8i exhibited broad–spectrum activity against selected pathogenic strains, with the MIC of 8 µg/mL for gram–positive bacteria (Staphylococcus aureus), 16 µg/mL for Pseudomonas aeruginosa (gram–negative bacteria), and Candida species, respectively. Future investigations with this class of compounds may lead to the development of potential candidates for antimicrobial drug discovery.Â