Open AccessSYNTHESIS, CHARACTERIZATION, AND ANTHELMINTIC ACTIVITY OF NOVEL BENZOTHIAZOLE DERIVATIVES CONTAINING INDOLE MOIETIES
Author(s) -
Aleti Rajareddy,
Srinivas Murthy M
Publication year - 2019
Publication title -
asian journal of pharmaceutical and clinical research
Language(s) - English
Resource type - Journals
eISSN - 2455-3891
pISSN - 0974-2441
DOI - 10.22159/ajpcr.2019.v12i3.30530
Subject(s) - benzothiazole , isatin , anthelmintic , chemistry , albendazole , fourier transform infrared spectroscopy , indole test , molecule , stereochemistry , combinatorial chemistry , organic chemistry , biology , ecology , physics , quantum mechanics
Objective: The objective of this study was to synthesize and evaluate the anthelmintic activity (AA) of novel benzothiazole derivatives containing indole moieties (BDIM).
Methods: The present works which involve the substituted isatin Schiff bases undergo acetylating and reacting with 2-aminobenzothiazole to give novel BDIM.
Results: All the newly synthesized molecules (5a-5o) were characterized by Fourier-transform infrared spectroscopy, H_nuclear magnetic resonance, and mass spectral analysis along with physical data. The biological potentials of the newly synthesized compounds are evaluated for their AA using an Indian earthworm (Pheretima posthuma), and albendazole was used as standard drug.
Conclusion: The synthesized compound 5f, 5n, and 5o showed good AA, whereas others exhibited significant activities.