Open AccessIN VITRO STUDY OF ANTIMICROBIAL AND ANTIOXIDANT ACTIVITIES OF OXALIC ACID-DERIVED BIOACTIVE CHELATING AGENT
Author(s) -
Daisy Selasteen F,
Alfred Cecil Raj S
Publication year - 2019
Publication title -
asian journal of pharmaceutical and clinical research
Language(s) - English
Resource type - Journals
eISSN - 2455-3891
pISSN - 0974-2441
DOI - 10.22159/ajpcr.2019.v12i2.29193
Subject(s) - chelation , chemistry , solubility , nuclear chemistry , antioxidant , distilled water , oxalic acid , oxalate , antimicrobial , cadmium oxide , inorganic chemistry , cadmium , organic chemistry , chromatography
Objective: The aim of this study is to evaluate the biological potentials of sodium cadmium oxalate dihydrate complex prepared by a single diffusion method in the silica gel medium.
Methods: The present complex was derived by the oxalic acid using a single diffusion method in gel medium and tested for single-crystal X-ray diffraction, ultraviolet-visible (UV) spectrum (190–500 mm), and solubility (distilled water at 20–29°C) studies. Antioxidant activity was determined by 2, 2-diphenyl-1-picrylhydrazyl assay, and antimicrobial activity was measured by agar well diffusion method.
Results: The present chelating complex was successfully synthesized by gel technique. The solubility of sodium cadmium oxalate dihydrate was moderately good for deionized warm water. The UV spectral studies confirmed the chelating O-H, Na-O, and C-O bonds of the newly synthesized complex for the optical and biological properties.
Conclusions: The metal-oxygen and oxygen-hydrogen bonds of the present newly synthesized sample much improved its optical, antimicrobial, and antioxidant activities and find its applications in the field of pharmaceutical and biomedical applications.