Open AccessANTICANCER ACTIVITY OF ZINC OXIDE AND ZINC OXIDE/CADMIUM SULFIDE NANOCOMPOSITES
Author(s) -
Ali Jabbar Jasim Makkawi,
Noor Hadi Aysa,
Fattima-Alzahra G Gassim
Publication year - 2019
Publication title -
asian journal of pharmaceutical and clinical research
Language(s) - English
Resource type - Journals
eISSN - 2455-3891
pISSN - 0974-2441
DOI - 10.22159/ajpcr.2019.v12i2.26265
Subject(s) - zinc , nuclear chemistry , nanoparticle , fourier transform infrared spectroscopy , nanocomposite , cadmium sulfide , chemistry , materials science , scanning electron microscope , inorganic chemistry , nanotechnology , chemical engineering , organic chemistry , engineering , composite material
Objective: The objective of this study is to investigate the anticancer activity of zinc oxide (ZnO) and ZnO/cadmium sulfide (CdS) nanoparticles (NPs). These NPs were active index against five human tumor cell lines, namely hepatocellular carcinoma, mammary gland (MCF-7), epidermoid carcinoma (HEP2), colorectal carcinoma (HCT-116), and rhabdomyosarcoma (RD).
Methods: ZnO and ZnO/CdS NPs were synthesized using zinc acetate dihydrate and oxalic acid. The samples are characterized by Fourier-transform infrared spectroscopy, X-ray diffraction, scanning electron microscopy, energy-dispersive X-ray spectroscopy, and atomic force microscopy (AFM).
Results: The results were indicated that these NPs can be used to made drug delivery system depending on ZnO and ZnO/CdS nanocomposites for its potential role in enhancing the anticancer efficacy of doxorubicin as well as work on reducing side effects.
Conclusions: ZnO and ZnO/CdS nanocomposites can be used anticancer for five human tumor cells.