Open AccessTHE ROLE OF SELENIUM MICRONUTRIENTS AS ANTIOXIDANTS IN EXPOSURE TO E-CIGARETTE SMOKE
Author(s) -
Rivan Virlando Suryadinata,
Merryana Adriani,
Santi Martini,
Sri Sumarmi,
Bambang Wirjatmadi
Publication year - 2019
Publication title -
asian journal of pharmaceutical and clinical research
Language(s) - English
Resource type - Journals
eISSN - 2455-3891
pISSN - 0974-2441
DOI - 10.22159/ajpcr.2019.v12i18.34454
Subject(s) - glutathione peroxidase , micronutrient , antioxidant , malondialdehyde , smoke , superoxide dismutase , cigarette smoke , selenium , chemistry , food science , pharmacology , medicine , biochemistry , environmental health , organic chemistry
Objective: E-cigarette products have resulted in various controversies concerning their posed impacts on health. Some argue that exposure to e-cigarette smoke could improve free radicals in the body; thus, it causes harming impacts on health. Peroral selenium (Se) administration can increase superoxide dismutase (SOD) and glutathione peroxidase (GPx) serving as antioxidants in the body.
Methods: This research is an experimental study aiming to analyze the effectiveness of Se to decrease free radical due to exposure to e-cigarette smoke as one of the preventive actions. The research was carried out to male Wistar rats with exposure to e-cigarette smoke and peroral Se intake with different time and duration of administration.
Results: Research results showed a decrease of antioxidant SOD and GPx in the administration of exposure to e-cigarette smoke, and they gradually increased after Se administration (p=0.000). Meanwhile, the malondialdehyde level was inversely proportional compared to antioxidant SOD and GPx.
Conclusion: Se is a micronutrient that can reduce free radicals due to exposure to e-cigarette smoke through enhancement of antioxidant enzymes such as SOD and GPx.