Open AccessBIOSYNTHESIS, CHARACTERIZATION, AND ANTI-INFLAMMATORY STUDY OF HEMIGRAPHIS COLORATA LOADED SILVER NANOPARTICLES
Author(s) -
Liji Thomas,
Saleena Mathew
Publication year - 2019
Publication title -
asian journal of pharmaceutical and clinical research
Language(s) - English
Resource type - Journals
eISSN - 2455-3891
pISSN - 0974-2441
DOI - 10.22159/ajpcr.2019.v12i10.35116
Subject(s) - anti inflammatory , silver nanoparticle , chemistry , polyphenol , in vitro , absorbance , pharmacology , biochemistry , antioxidant , nanoparticle , nanotechnology , chromatography , biology , materials science
Objective: This study targeted at the synthesis, characterization, and evaluation of the anti-inflammatory effects of Hemigraphis colorata silver nanopartilces (HAgNPs).
Methods: The HAgNPs were photosynthesized and characterized by UV-visible spectroscopy. The in vitro anti-inflammatory properties of HAgNPs were assessed by evaluating inhibition of protein denaturation and membrane stabilization ability assay.
Results: HAgNPs exhibited an absorbance peak at 450 nm, characteristic for AgNPs, and their sizes ranged from 20 to 90 nm. The anti-inflammatory potential of HAgNPs when compared with H. colorata extract suggests that the AgNPs along with polyphenols and flavonoids from H. colorata can act as reducing or inhibiting agent on the release of acute inflammatory mediators.
Conclusion: The biologically synthesized HAgNPs could be of enormous use in the medical field for their proficient anti-inflammatory activity, which can be utilized as novel therapeutic agent for prevention and cure of inflammation due to biocompatible nature. This work clearly demonstrates HAgNPs as a budding source for anti-inflammatory drugs.