Open AccessEFFECT OF NOISE STRESS-INDUCED NEUROBEHAVIORAL CHANGES ON WISTAR ALBINO RATS
Author(s) -
Archana Arjunan,
Ravindran Rajan
Publication year - 2019
Publication title -
asian journal of pharmaceutical and clinical research
Language(s) - English
Resource type - Journals
eISSN - 2455-3891
pISSN - 0974-2441
DOI - 10.22159/ajpcr.2019.v12i10.34843
Subject(s) - open field , elevated plus maze , cognition , anxiety , psychology , behavioural despair test , noise (video) , medicine , animal model , physiology , developmental psychology , neuroscience , psychiatry , artificial intelligence , computer science , image (mathematics) , antidepressant
Objective: The study aims to investigate the effect of acute noise stress on cognitive functions in male Wistar albino rats.
Methods: Adult albino rats were randomly divided into two groups. Each group contains six animals. Rats exposed to acute noise stress (100 dB/4 h) were compared with control animal and assessed for cognition using T-maze, hole-board test, open-field test, marble burying test, and social interaction behavior.
Results: The rats exposed to acute noise stress showed the significance (p<0.05) of behavioral alterations such as impaired learning and memory, memory retention, increased fear and anxiety, obsessive–compulsive behavior, social avoidance, and decreased social interaction.
Conclusion: The results report that acute noise stress affects the cognition, and it became chronic may confer the increased risk of neurodegenerative disorders.