Open AccessBIOMARKER POTENTIAL OF IQ-DOMAIN GTPASE-ACTIVATING PROTEINS FAMILY PROTEIN IN PANCREATIC CANCER: A MINI REVIEW
Author(s) -
Anton Sumarpo,
Agnes Anania Triavika Sahamastuti,
Gisella Edny Tjugianto,
Kenny Yonathan,
David Agustriawan
Publication year - 2018
Publication title -
asian journal of pharmaceutical and clinical research
Language(s) - English
Resource type - Journals
eISSN - 2455-3891
pISSN - 0974-2441
DOI - 10.22159/ajpcr.2018.v11s3.30021
Subject(s) - biomarker , pancreatic cancer , carcinogenesis , iqgap1 , medicine , cancer , cancer research , oncology , bioinformatics , biology , signal transduction , genetics , scaffold protein
Objectives: Our present study was done to understand molecular regulatory mechanisms of IQGAP proteins and their potentials as biomarker in pancreatic cancer.Methods: In this review, relevant studies were obtained by assessing the PubMed database using the combination of words that included “IQGAP” and “pancreatic cancer”.Results: There is an increasing evidence showing that the expression of IQGAP1 and IQGAP3 is positively correlated with tumorigenesis; however, IQGAP2 might play a role to suppress tumor progression.Conclusion: IQGAP proteins might have potentials as predictive and prognostic biomarker for human pancreatic cancer.