Open AccessANTIOXIDANT ACTIVITY OF ALKALOID FRACTIONS OF LITSEA CUBEBA LOUR. FRUITS
Author(s) -
Aminah Dalimunthe,
Poppy Anjelisa Zaitun Hasibuan,
Jansen Silalahi,
Denny Satria
Publication year - 2018
Publication title -
asian journal of pharmaceutical and clinical research
Language(s) - English
Resource type - Journals
eISSN - 2455-3891
pISSN - 0974-2441
DOI - 10.22159/ajpcr.2018.v11s1.26558
Subject(s) - alkaloid , maceration (sewage) , chemistry , antioxidant , traditional medicine , chloroform , extraction (chemistry) , chromatography , stereochemistry , organic chemistry , medicine , materials science , composite material
Objective: The oxidation induced by free radicals results in many degenerative disease. The purpose of this study is to determine antioxidant activities of alkaloid fractions of Litsea cubeba (Lour.) fruit.Methods: L. cubeba Lour. was extracted by maceration. Ethanol extract was fractionated with liquid-liquid extraction using n-hexane and chloroform at pH 3, 7, 9, and 11 to obtained alkaloid fractions. Antioxidant activity for extract and fractions was determined with 1,1-diphenyl-2-picrylhydrazyl.Results: The IC50 of extract and fractions was 219.43±0.43, 242.97±0.93, 92.38±0.17, 40.84±0.04, 103.83±3.29, and 103.75±0.42 μg/mL, respectively.Conclusion: The results reveal that alkaloid fractions of L. cubeba fruits have very strong antioxidant potential. Our further study is to isolate the alkaloid compounds.