Open AccessFORMULATION AND EVALUATION OF RED PALM OLEIN NANOEMULSION
Author(s) -
Febia Sari,
Kasmirul Ramlan Sinaga,
Donald Siahaan
Publication year - 2018
Publication title -
asian journal of pharmaceutical and clinical research
Language(s) - English
Resource type - Journals
eISSN - 2455-3891
pISSN - 0974-2441
DOI - 10.22159/ajpcr.2018.v11i9.26532
Subject(s) - chromatography , viscosity , organoleptic , odor , particle size , pulmonary surfactant , chemistry , materials science , food science , composite material , organic chemistry , biochemistry
Objective: The objective of this study is to formulate and evaluate the red palm olein (RPO) nanoemulsion using spontaneous emulsification method.Methods: Nanoemulsion formulated by spontaneous emulsification method using the comparison of surfactant (tween 80) and cosurfactant (sorbitol) concentration with the variation of RPO concentration. Evaluation of the stability of the nanoemulsion preparation includes centrifugation test, viscosity, pH, organoleptic observation (odor, color, clarity, and phase separation), and particle size measurement during 12 weeks storage at room temperature.Result: The results showed that all nanoemulsion preparations were transparent yellow, characteristic odor, type weights 1.0166–1.0641 g/ml, and stable for 12 weeks storage at room temperature. The smallest particle size was produced by the nanoemulsion preparation in a formula of the concentration of 5%, which was 67, 64 nm.Conclusion: RPO can be formulated as a nanoemulsion by spontaneous emulsification method. RPO with a 5% concentration is very stable for 12 weeks storage.