Open AccessFABRICATION AND EVALUATION OF SOLID DISPERSION CONTAINING GLIBENCLAMIDE
Author(s) -
Nikita Sehgal,
Vishal Gupta N,
Gowda Dv,
Praveen Sivadasu
Publication year - 2018
Publication title -
asian journal of pharmaceutical and clinical research
Language(s) - English
Resource type - Journals
eISSN - 2455-3891
pISSN - 0974-2441
DOI - 10.22159/ajpcr.2018.v11i8.26236
Subject(s) - dissolution , differential scanning calorimetry , amorphous solid , dispersion (optics) , materials science , scanning electron microscope , solubility , chemical engineering , glibenclamide , poloxamer , nuclear chemistry , chemistry , crystallography , organic chemistry , composite material , polymer , thermodynamics , medicine , copolymer , optics , physics , diabetes mellitus , engineering , endocrinology
Objective: The aim of the present study was to increase the dissolution rate of glibenclamide (GLIB) by molecular dispersion of drug in the polymeric matrix of Pluronic F-127.Methods: GLIB-loaded solid dispersions were formulated by fusion method. The formulated solid dispersions were characterized for scanning electron microscopy (SEM), X-ray diffractometry (XRD), differential scanning calorimetry (DSC), and evaluated for percentage yield, drug content, solubility, and in vitro dissolution profile, and stability studies were conducted as per International Conference on Harmonisation guidelines Q1A in stability chamber, both at intermediate and accelerated conditions.Results: Both XRD and DSC studies suggested that crystalline GLIB was converted to amorphous form after loading into carrier. SEM studies revealed that the prepared solid dispersions were in the form of irregular particles with the absence of crystalline material. Due to this conversion of crystalline to amorphous state, formulated solid dispersions had shown improved dissolution rate profile of GLIB and stability studies suggested that formulated solid dispersions showed no significant changes in appearance and also in drug content.Conclusion: Thus, from the obtained results, it can be concluded that dissolution profile of GLIB can be improved by formulating as solid dispersion.