Open AccessRESTORATIVE EFFECTS OF ZINGIBER OFFICINALE ON ARSENIC-INDUCED GENOTOXIC EFFECTS IN CHROMOSOMAL STRUCTURE OF MICE
Author(s) -
Sunil Sharma,
Anjali Singh Gill
Publication year - 2018
Publication title -
asian journal of pharmaceutical and clinical research
Language(s) - English
Resource type - Journals
eISSN - 2455-3891
pISSN - 0974-2441
DOI - 10.22159/ajpcr.2018.v11i7.26505
Subject(s) - arsenic trioxide , zingiber officinale , genotoxicity , arsenic , micronucleus test , clastogen , micronucleus , traditional medicine , chemistry , pharmacology , toxicology , biology , toxicity , medicine , organic chemistry
Objective: The present study investigated the antigenotoxic effect of Zingiber officinale (Ginger) on arsenic-induced genotoxic effects in chromosome structure of Swiss albino mice.Methods: Albino mice were divided into four groups: Group I was kept as control, Group II was administrated an oral dose of arsenic trioxide 5 mg/kg bw for 15 days, Group III was given an oral dose of arsenic trioxide 5 mg/kg bw followed by 20 mg/kg bw of ginger orally, and Group IV was administered with 20 mg/kg bw of ginger orally for 15 days and kept as positive control. The autopsies were done from all the groups on 15-day post-treatment, and bone marrow was removed for chromosomal study and for calculating the frequency of micronuclei (MN).Results: It is concluded from this study that long-term arsenic exposure causes chromosomal anomalies, for example, breaks, gaps, rings, stretching, and stickiness which leads to the fragmentation of chromosomes and increases the frequency of MN.Conclusion: The administration of ginger showed modulatory effects against arsenic-induced genotoxicity.