Open AccessTHERAPEUTIC IMPACT OF BERRIES (MORUS ALBA AND MORUS RUBRA) FRUIT EXTRACT IN THE REGRESSION OF HIGH-FAT DIET-INDUCED CARDIAC DYSFUNCTION IN RATS
Author(s) -
Farouk K. El Baz,
Hanan F. Aly,
Howaida I. AbdAlla,
Dalia F Biomy
Publication year - 2018
Publication title -
asian journal of pharmaceutical and clinical research
Language(s) - English
Resource type - Journals
eISSN - 2455-3891
pISSN - 0974-2441
DOI - 10.22159/ajpcr.2018.v11i7.25859
Subject(s) - cardiac fibrosis , medicine , adiponectin , fibrosis , endocrinology , plasminogen activator inhibitor 1 , plasminogen activator , obesity , insulin resistance
Objective: The aim of the present study is to investigate the effect of Morus alba (MA) and Morus rubra L. (MR) fruit extract on obesity-induced cardiac dysfunction and fibrosis in cardiac tissue.Methods: Seventy male Wistar albino rats were randomly divided into five groups of ten rats each. MA and MR have been administered for 6 weeks in obese rats induced by high-fat diet (HFD). Adiponectin, glucagon, troponin, plasminogen activator inhibitor, cell adhesion molecules-1 (intracellular and vascular respectively), C-reactive protein, collagen type II and collagen alpha-1 (III) chain, and lipoxygenase activity were also estimated in serum of obese rats. Histopathological investigation of cardiac tissue was carried out.Results: MA and MR treatments significantly normalized cardiac dysfunction biomarkers as well as cardiac fibrosis as examined by histopathological examination with higher percentage of improvement for MR extract.Conclusion: Hence, it could be concluded that MA and MR extracts have useful effects on obesity-associated cardiac diseases through lipid metabolism regulation, cardiac functions and reversed cardiac fibrosis.