Open AccessPROTECTIVE ROLE OF AERVA MONSONIAE AND SELENIUM ON CADMIUM- INDUCED OXIDATIVE LIVER DAMAGE IN RATS
Author(s) -
Divya Jyothi Palati,
Swaroopa Rani Vanapatla
Publication year - 2018
Publication title -
asian journal of pharmaceutical and clinical research
Language(s) - English
Resource type - Journals
eISSN - 2455-3891
pISSN - 0974-2441
DOI - 10.22159/ajpcr.2018.v11i6.24112
Subject(s) - chemistry , malondialdehyde , oxidative stress , bilirubin , alkaline phosphatase , superoxide dismutase , selenium , catalase , pharmacology , cadmium , glutathione , medicine , endocrinology , biochemistry , enzyme , organic chemistry
Objective: The present study was aimed to investigate the protective effect of methanolic extract of the whole plant of Aerva monsoniae (MEAM) and selenium on cadmium (Cd)-induced oxidative liver damage in experimental rats.Methods: In the present study, albino Wistar rats were treated with Cd (5 mg/kg), selenium (1 mg/kg), and MEAM (250 and 500 mg/kg) for 21days. After 21 days of the treatment, the rats were sacrificed, and blood was collected for estimation of biochemical parameters and liver was used for histopathological studies.Results: Oral administration of Cd significantly elevated the levels of hepatic markers such as alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, γ-glutamyl transferase, cholesterol, total bilirubin, direct bilirubin, and decreased levels of total proteins and albumin. We also observed that elevated oxidative stress markers such as malondialdehyde reduced the enzymatic antioxidants such as superoxide dismutase, catalase, and non-enzymatic antioxidants such as reduced glutathione in the liver. Co-administration of MEAM and selenium in Cd-intoxicated rats, the altered biochemical parameters, and pathological changes were recovered significantly (p>0.01) than the individual effects of MEAM and selenium.Conclusion: From the above findings, it was concluded that combination of MEAM and selenium exhibited remarkable protective effects against Cd-induced oxidative liver damage in rats.