Open AccessINCIDENCE OF HEMATOLOGICAL MALIGNANCIES IN SICKLE CELL PATIENTS FROM AN INDIAN TERTIARY CARE TEACHING HOSPITAL
Author(s) -
Sima Chauhan,
Santosh Kumar Swain,
Mahesh Chandra Sahu
Publication year - 2018
Publication title -
asian journal of pharmaceutical and clinical research
Language(s) - English
Resource type - Journals
eISSN - 2455-3891
pISSN - 0974-2441
DOI - 10.22159/ajpcr.2018.v11i3.22790
Subject(s) - medicine , incidence (geometry) , bone marrow , malignancy , biopsy , anemia , sickle cell anemia , disease , population , cancer , gastroenterology , pathology , physics , environmental health , optics
Objective: Sickle cell disease (SCD) involves multiple systems and is manifested by variable degree of anemia, acute vaso-occlusive episodes, and chronic organ damage. Small case series have hinted at increased incidence of cancer among SCD patients, but no examination of population-based data in Odisha has been reported. Here, we have reported the association of hematological malignancies and SCD in our region.Methods: In this prospective study, we have documented all the demographic and clinical data of sickle cell patients during the past 3 years from June 2013 to May 2016. Simultaneously, the bone marrow (BM) aspiration and biopsy were carried out for all patients. This study was approved from the Institutional Ethics Committee.Results: A total number of 267 sickle cell patients were screened for malignancy by both BM aspiration and biopsy. Among them, 6 cases of malignancies were detected by both BM aspiration and biopsy method.Conclusion: Our study shows a association between SCD and hematological malignancies which could be due to treatment with hydroxyurea or accumulation of multiple genetic abnormalities due to a high degree of proliferative activity of marrow cells.