Open AccessNARINGIN REVEALS AMELIORATIVE PROPERTY OVER ELEVATED OXIDATIVE STRESS LEVELS IN ANIMAL MODELS
Author(s) -
Zorawar Singh,
Adeshwinder Kaur,
Shivam Sharma
Publication year - 2018
Publication title -
asian journal of pharmaceutical and clinical research
Language(s) - English
Resource type - Journals
eISSN - 2455-3891
pISSN - 0974-2441
DOI - 10.22159/ajpcr.2018.v11i12.25318
Subject(s) - naringin , oxidative stress , phytochemical , neurodegeneration , antioxidant , oxidative damage , dna damage , pharmacology , chemistry , medicine , biology , bioinformatics , biochemistry , dna , genetics , disease
Oxidative stress (OxiS) has been implicated in the pathogenesis of many diseases. Free radicals interact with different cell components including DNA, proteins, and lipids to become stable. In this process, these free radicals damage the integrity of these biological moieties and result in various health implications. Naringin (NG), a naturally occurring phytochemical commonly found in grapefruit juice has been explored for its protective role against OxiS. In this short review paper, an attempt has been made to compile the study reports revealing the antioxidative nature of NG in different animal models. Studies have reported NG as a potential antioxidant in various health ailments including diabetes, cardiac fibrosis, cognitive dysfunction, and neurodegeneration.