Open AccessCORRELATION BETWEEN PHYTOESTROGENS INTAKE WITH TELOMERE LENGTH IN MINANGKABAU PREMENOPAUSAL WOMEN
Author(s) -
Desmawati Desmawati,
Delmi Sulastri,
Yuniar Lestari,
Jamsari Jamsari
Publication year - 2018
Publication title -
asian journal of pharmaceutical and clinical research
Language(s) - English
Resource type - Journals
eISSN - 2455-3891
pISSN - 0974-2441
DOI - 10.22159/ajpcr.2018.v11i11.29509
Subject(s) - phytoestrogens , telomere , correlation , medicine , positive correlation , physiology , endocrinology , zoology , biology , estrogen , genetics , gene , mathematics , geometry
Objective: This study aimed to investigate the correlation between phytoestrogens intake with telomere length in premenopausal Minangkabau ethnicity women.Methods: This cross-sectional study was conducted in Padang city, to 113 premenopausal Minangkabau ethnic 40–54 years old. Food intake data were obtained by an interview by trained enumerators using semi-quantitative food frequency questionnaire. Telomere examination was done from 3 ml of venous blood. Telomere length examination by modification of O’Callaghan and Fenech method. Estradiol level was measured by the ELISA technique.Results: This research indicated an average telomere length was 554.79±426.81 bp, estradiol level was 149.47±52.26 pg/ml, and phytoestrogens intake was 37.95±32.25 mg/day. There were the differences between phytoestrogens intake and telomere length based on estradiol levels. Then, there was no significant correlation between phytoestrogens intake and telomere length.Conclusion: There is no significant positive correlation between phytoestrogens intake and telomere length of premenopausal women in the Minangkabau ethnic.