Open AccessSARGASSUM POLYCYSTUM METHANOL EXTRACT AFFECTS THE NUCLEAR FACTOR-k BETA AND INTERLEUKIN-6 EXPRESSION IN STREPTOZOTOCIN-INDUCED DIABETES RATS
Author(s) -
Muhamad Firdaus,
Anies Chamidah
Publication year - 2018
Publication title -
asian journal of pharmaceutical and clinical research
Language(s) - English
Resource type - Journals
eISSN - 2455-3891
pISSN - 0974-2441
DOI - 10.22159/ajpcr.2018.v11i11.27658
Subject(s) - streptozotocin , diabetes mellitus , medicine , endocrinology , gliclazide
Objective: The objective of this study is to investigate the attenuation of the nuclear factor-κ beta (NF-κB) and interleukin (IL)-6 expression in streptozotocin-induced diabetic rats by Sargassum polycystum methanol extract.Methods: Diabetic rats were intraperitoneally induced by streptozotocin (40 mg/kg b.w.). S. polycystum methanol extract was administered to diabetic rats for 45 days. The effect of S. polycystum methanol extract on blood glucose, hemoglobin A1c (HbA1c), NF-κB, and IL-6 expression was investigated on streptozotocin-induced diabetic rats. The gliclazide (30 mg/kg b.w., p.o.) was used as a reference antidiabetic drug.Results: The administration of S. polycystum methanol extract on streptozotocin-induced diabetic rats decreased the blood glucose level, HbA1c, NF-κB, and IL-6.Conclusion: S. polycystum methanol extract indicates a promising anti-inflammation agent in diabetes.