Open AccessA SYSTEMATIC REVIEW OF RISK FACTORS OF ADVERSE DRUG REACTIONS IN HOSPITALIZED PATIENTS
Author(s) -
Manoj Kumar Mudigubba,
M. Krishna Murthy,
Ann Mary Swaroop,
M Nayanatara,
Saurabh Dahiya
Publication year - 2018
Publication title -
asian journal of pharmaceutical and clinical research
Language(s) - English
Resource type - Journals
eISSN - 2455-3891
pISSN - 0974-2441
DOI - 10.22159/ajpcr.2018.v11i10.27759
Subject(s) - medicine , polypharmacy , scopus , medline , population , causality (physics) , systematic review , drug reaction , adverse drug reaction , risk factor , drug , intensive care medicine , emergency medicine , family medicine , pediatrics , psychiatry , environmental health , physics , quantum mechanics , political science , law
Background: Adverse drug reactions (ADRs) pose both financial and health encumbrances for patients. Although prevalence and risk factors associated with ADRs have been published in many studies, most of them lack the statistical evidence for predictors. The aim of this study was to review the published literature to determine the risk factors in the adult and elderly population for ADRs. An electronic search of articles published in English language in databases such as Cochrane Database of Systematic Reviews, MEDLINE, EMBASE, Scopus, and Google Scholar was conducted in between January 2001 and April 2018. The search terms used were: “ADRs,” “drug-related problems,” “risk factors,” “general adult population,” “elderly patients,” and “hospital admission.” For inclusion in the review, studies had to include an explicit definition of what was considered an ADR and/or an explicit assessment of causality, as well as a clear description of the method used for ADR identification. Polypharmacy was the major risk factor of ADR followed by comorbidities and length of hospital stay.