Open AccessIMMUNOHISTOCHEMICAL EXPRESSION OF C-KIT IN ORAL SQUAMOUS CELL CARCINOMA PATIENTS IN SOUTH INDIAN POPULATIONS
Author(s) -
Jayalalitha Sathiyamoorthy,
Vidyarani Shyamsundar,
Subbiah Shanmugam,
G. Gopu,
Rajeswary Hari
Publication year - 2018
Publication title -
asian journal of pharmaceutical and clinical research
Language(s) - English
Resource type - Journals
eISSN - 2455-3891
pISSN - 0974-2441
DOI - 10.22159/ajpcr.2018.v11i10.27443
Subject(s) - immunohistochemistry , basal cell , medicine , epithelial dysplasia , pathology , protein expression , overall survival , dysplasia , survival analysis , oncology , biology , gene , biochemistry
Objective: The study was designed to evaluate the C-Kit expression and also to assess the relationship with various clinicopathological characteristics in oral squamous cell carcinoma (OSCC) patients.Methods: A total number of 102 formalin-fixed paraffin-embedded retrospective tissue samples were collected, in which (n =84) were histologically confirmed for OSCC, oral epithelial dysplasia (OED) (n=9), and control group (n=10) and studied immunohistochemically. The baseline characters and the correlation between the protein expression and clinicopathological parameters were analyzed. The survival analysis was performed using Kaplan-Meier Survival Method.Results: OSCC exhibited C-Kit protein expression positivity of 6% and OED with 11.11% with no expression of this protein in control patients. Overall survival analysis showed that patients with negative expression had a better survival than patients with positive expression. However, we found that expression pattern of C-kit did not correlate with various clinicopathological characteristics.Conclusion: Vast amount of study has to be still performed to under the mechanism of OSCC in C-KIT Expression to enhance the prognosis of OSCC patients in the near future.