Open AccessFOLIC ACID, VITAMIN B12, AND DNA METHYLATION: AN UPDATE.
Author(s) -
Bhongir Aparna Varma,
Srilatha Bashetti,
R. Vijayaraghavan,
Kumar Sai Sailesh
Publication year - 2018
Publication title -
asian journal of pharmaceutical and clinical research
Language(s) - English
Resource type - Journals
eISSN - 2455-3891
pISSN - 0974-2441
DOI - 10.22159/ajpcr.2017.v11i1.21892
Subject(s) - dna methylation , methylation , vitamin b12 , epigenetics , dna , folic acid , biochemistry , uracil , methyltransferase , biology , thymidine , methionine , genetics , amino acid , gene , medicine , gene expression
Epigenetics is one of the exciting and fastest expanding fields of biology; this is above genetics. Methylation is the process involved in the transfer of methyl group to amino acids, proteins, enzymes and DNA of all the cells, and tissues of the body. During cell-division low folate availability may result in decreased production of thymidine wherein uracil may be substituted in the place of thymidine in the DNA sequence. It was reported that folate and Vitamin B12 restricted diet resulted in aberrant methylation patterns. The current review was undertaken to explore the role of folic acid and Vitamin B12 in DNA methylation.