Open AccessAMELIORATION OF ALUMINUM- AND FLUORIDE-INDUCED BEHAVIORAL ALTERATIONS THROUGH RESVERATROL IN RATS.
Author(s) -
Chandra Shakar Reddy Nallagouni,
Mesram Nageshwar,
Pratap Reddy Karnati
Publication year - 2018
Publication title -
asian journal of pharmaceutical and clinical research
Language(s) - English
Resource type - Journals
eISSN - 2455-3891
pISSN - 0974-2441
DOI - 10.22159/ajpcr.2017.v11i1.21620
Subject(s) - resveratrol , fluoride , sodium fluoride , chemistry , sodium , body weight , chloride , zoology , endocrinology , nuclear chemistry , biochemistry , medicine , inorganic chemistry , biology , organic chemistry
Objective: The objective of the study was to investigate the ameliorative effects of resveratrol against aluminum- and fluoride-altered neurobehavioral activities.Methods: Aluminum chloride (100 mg/kg body weight [bw])+sodium fluoride (10 mg/kg bw), aluminum chloride (100 mg/kg bw) + sodium fluoride (10 mg/kg bw) + resveratrol (30 mg/kg bw), and resveratrol (30 mg/kg bw) alone were given orally to II, III, and IV groups, respectively, and Group-I was served as control for 8 weeks. The bw, brain weight, grip strength, learning ability, and behavioral activities were assayed.Results: The results showed significantly (*p<0.05) altered body and brain weights, learning ability, grip strength, and behavioral activities in Group- II, whereas significant (*p<0.05) reversal was observed in Group-III.Conclusion: Taken together, the above findings conclude that resveratrol ameliorated aluminum and fluoride-altered neurobehavioral activities.