Open AccessTOXICOLOGICAL EVALUATION OF AYURVEDIC FORMULATION: GOKSHURADI GUGGULU
Author(s) -
Kanan Gamit,
Raval Manan A
Publication year - 2017
Publication title -
asian journal of pharmaceutical and clinical research
Language(s) - English
Resource type - Journals
eISSN - 2455-3891
pISSN - 0974-2441
DOI - 10.22159/ajpcr.2017.v10i9.19295
Subject(s) - toxicity , acute toxicity , traditional medicine , medicine , toxicology , pharmacology , biology
Objective: To evaluate toxicological studies of Ayurvedic formulation Gokshuradi Guggulu (GG) on male Wistar rats.Methods: Acute toxicity study was conducted as per the Organisation for Economic Co-operation and Development guidelines.Results: Results from the present study have elucidated that treatment with GS exerted no significant signs of toxicity at dose level 2000 mg/kg body wt. There was no mortality observed in all the groups. Behavioral, biochemical, and hematological parameters and histopathological studies were not significantly much altered as compared to control group.Conclusion: LD50 for GS was >2000 mg/kg. Thus, it is regarded as safe or non-toxic.