Open AccessLAMOTRIGINE INDUCED DRESS SYNDROME
Author(s) -
Saurab Agarwal,
Balaji Ommurugan,
Amita Priya,
Mohan Babu Amberkar,
Meena Kumari Kamalkishore
Publication year - 2017
Publication title -
asian journal of pharmaceutical and clinical research
Language(s) - English
Resource type - Journals
eISSN - 2455-3891
pISSN - 0974-2441
DOI - 10.22159/ajpcr.2017.v10i9.18876
Subject(s) - lamotrigine , rash , eosinophilia , medicine , dermatology , culprit , incidence (geometry) , hepatitis , epilepsy , hypersensitivity reaction , pediatrics , immunology , psychiatry , physics , myocardial infarction , optics
Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome, is a type of hypersensitivity reaction, mainly due to anti-epileptic drugs. Lamotrigine is a newer broad spectrum antiepileptic that can be used in both children and adults. Lamotrigine induced DRESS syndrome is a rare case with incidence of 1/1000 to 1/10000. This syndrome manifests as rash, fever, tender lymphadenopathies, hepatitis, and eosinophilia. This case highlights the need for early diagnosis and treatment of such a rare and life threatening event because early detection of the condition leads to early recovery of the patient. Further re-exposure to the drug should be avoided.