Open AccessEFFECT OF GREEN SYNTHESIZED SILVER NANOPARTICLES ON QUORUM SENSING INHIBITION OF UTI PATHOGENS
Author(s) -
Shaheen Sheikh,
Vidya Tale
Publication year - 2017
Publication title -
asian journal of pharmaceutical and clinical research
Language(s) - English
Resource type - Journals
eISSN - 2455-3891
pISSN - 0974-2441
DOI - 10.22159/ajpcr.2017.v10i5.16949
Subject(s) - quorum sensing , chromobacterium violaceum , antimicrobial , bacteria , autoinducer , chemistry , microbiology and biotechnology , silver nanoparticle , pathogenic bacteria , biofilm , nanoparticle , biology , nanotechnology , materials science , genetics
Objective: The present study was conducted to evaluate the antimicrobial and anti-quorum sensing (QS) ability of nanoparticles synthesized usingfruit wastes.Methods: QS is a system of response and stimuli correlated to population density. Bacteria by QS secrete certain signaling molecules called autoinducers. These bacteria also have a receptor that can specifically detect the signaling molecule known as an inducer. Since QS governs numerous processes in bacteria including virulence, QS inhibition promises to be an ideal target for the development of novel therapeutics. In the present study, silver nanoparticles (AgNPs) synthesized from the ginger, lemon peel, cinnamon, corn silk, pomegranate peel, and orange peel exhibited anti-QS properties by inhibiting violacein production in Chromobacterium violaceum assayed using agar well diffusion method.Results: AgNPs were synthesized from various cost-effective fruit waste sources. These AgNPs exhibited significant antibacterial and anti-QS properties.Conclusion: Hence, such sources can be explored for developing the effective therapy for urinary tract infections.Keywords: Silver nanoparticles, Quorum sensing, Urinary Tract infection.