Open AccessEVALUATION OF ANTIHYPERLIPIDEMIC ACTIVITY OF LEAVES OF ACHYRANTHES ASPERA Linn USING HYPERLIPIDEMIC RATS
Author(s) -
Sarvesh Cn,
J. Fernandes
Publication year - 2017
Publication title -
asian journal of pharmaceutical and clinical research
Language(s) - English
Resource type - Journals
eISSN - 2455-3891
pISSN - 0974-2441
DOI - 10.22159/ajpcr.2017.v10i4.16576
Subject(s) - achyranthes aspera , hyperlipidemia , atorvastatin , traditional medicine , triglyceride , saline , pharmacology , aqueous extract , chemistry , low density lipoprotein , diuretic , cholesterol , medicine , biochemistry , endocrinology , diabetes mellitus , alternative medicine , pathology
Objective: Plants have been one of the important sources of medicines since the beginning of human civilization. Achyranthes aspera Linn. belongingto family Amaranthaceae, commonly found in India. The plant is used as antiarthritic, purgative, diuretic, antimalarial, etc.Methods: The antihyperlipidemic activity of alcoholic and aqueous extracts of leaves of A. aspera was evaluated using triton-induced hyperlipidemiamodel in albino Wistar rats. The acute toxicity study confirmed that both the extracts were found to be safe at 5000 mg/kg b.w. in female albinoWistar rats. In this model, eight groups (six animals per group) of animals were used. Group I and II were considered as saline and hyperlipidemiccontrols, respectively, and other groups received their respective agents (alcoholic or aqueous extract/atorvastatin/ayurvedic preparation) and all thegroups received triton WR1339 (200 mg/kg b.w. i.v.) except saline control group. Serum cholesterol and triglycerides (TGs) level are estimated for theevaluation of antihyperlipidemic effects of extracts.Results: The ethanolic extract has shown a significant reduction in serum cholesterol and TGs level indicating antihyperlipidemic potentials in theplant while aqueous extract has not shown any beneficial effect.Conclusion: In this triton-induced hyperlipidemia model, serum and TG levels were analyzed ethanolic extract was shown antihyperlipidemic activity.Further clinical studies are compulsory to confirm the findings.Keywords: Achyranthes aspera, High-density lipoprotein, Low-density lipoprotein, Triglyceride, Total cholesterol, Triton, Antihyperlipidemic.