Open AccessEVALUATION OF ANTIMICROBIAL ACTIVITY OF GREEN-SYNTHESIZED MANGANESE OXIDE NANOPARTICLES AND COMPARATIVE STUDIES WITH CURCUMINANILINE FUNCTIONALIZED NANOFORM
Author(s) -
Muhamed Haneefa M,
M. Jayandran,
. Balasubramanian
Publication year - 2017
Publication title -
asian journal of pharmaceutical and clinical research
Language(s) - English
Resource type - Journals
eISSN - 2455-3891
pISSN - 0974-2441
DOI - 10.22159/ajpcr.2017.v10i3.16246
Subject(s) - antimicrobial , curcumin , nanoparticle , antifungal , materials science , nanotechnology , manganese , nuclear chemistry , antibacterial activity , fourier transform infrared spectroscopy , nanobiotechnology , chemistry , chemical engineering , organic chemistry , bacteria , biochemistry , microbiology and biotechnology , biology , genetics , engineering
Objective: Metal oxide nanoparticles are widely attracted researchers due to their potential applications in a variety of fields, especially medicinalimportance. It has been shown that biofunctionalization of metal nanoparticles with the specified bioactive materials produces the significantlyimproved bioactive materials with the essential biological properties and advanced features. According to the reports, manganese oxide nanoparticles(MONPs) possess highly magnetic properties leads to develop for use in research and biomedical applications. In this evaluation, we focused on thesynthesis of MONPs through a green methodology and their antimicrobial activity changes when functionalized with curcuminaniline derived fromturmeric plants.Methods: First, curcumin has been isolated from turmeric plant (BSR-01) to synthesize curcuminaniline biomaterial. On the other hand, manganesenanoparticles are synthesized by the green synthesis method using lemon extract and curcumin. Finally, the synthesized curcuminaniline isfunctionalized with MONPs. The synthesized nanoparticles are characterized by ultraviolet-visible, Fourier transform infrared, scanning electronmicroscope and transmission electron microscopy techniques. The antimicrobial activity of the obtained nonfunctionalized and biofunctionalizednanoforms are tested against some Gram-negative and Gram-positive bacterial strains as well as fungal strains.Results: The morphological studies represented that MONPs are of eclipsed and spherical morphology with size about 50±5 nm and biofunctionalizednanoparticles are of spherical morphology with size about 50±10 nm. The antibacterial and antifungal tests revealed that biofunctionalized MONPsare exhibited significantly higher antimicrobial activity.Conclusion: This investigation clearly demonstrated that MONPs are shown significantly higher biocidal activity when biofunctionalized withmodified curcumin material. This may help in the future medicinal and pharmaceutical industries to develop new inventions.Keywords: Green synthesis, Nanoparticles, Curcumin, Curcuminaniline, Soxhlet extraction, Antimicrobial activity.