Open AccessEVALUATION OF ANTIULCEROGENIC ACTIVITY OF METHANOL EXTRACTS OF BRASSICA OLERACEA VAR. CAPITATA RUBRA ON ALBINO RAT GASTRIC ULCERATION
Author(s) -
K. Sudha Rameshwari,
M Ayshwarya
Publication year - 2017
Publication title -
asian journal of pharmaceutical and clinical research
Language(s) - English
Resource type - Journals
eISSN - 2455-3891
pISSN - 0974-2441
DOI - 10.22159/ajpcr.2017.v10i3.16217
Subject(s) - capitata , brassica oleracea , ranitidine , traditional medicine , ulcer index , brassica , methanol , medicine , stomach , chemistry , pharmacology , botany , biochemistry , gastric mucosa , biology , organic chemistry
Objective: To investigate the antiulcerogenic activity of methanolic extract of Brassica var. capitata rubra in albino rats.Methods: To evaluate the antiulcer activity by pyloric ligation models experimentally induced gastric ulcer by ranitidine (10 mg/kg) subcutaneously.The parameters taken to assess antiulcer activity were free acidity, total acidity, volume of gastric juice, PH, ulcer score, and ulcer index.Results: The methanolic extract of Brassica oleracea var. capitata rubra in the dose of 0.50 mg/kg produced significant antiulcer activity. The controlanimals had ulcers and hemorrhagic streaks, whereas in animals administered with extracts of B. oleracea there was a significant reduction in ulcerindex (p˂0.05).Conclusion: This study concluded that methanol extract of B. oleracea var. capitata has healing property of gastric ulcers in albino rats.Keywords: Brassica, Methanol extract, Antiulcer activity, Pyloric ligation model.