Open AccessTHE MAJOR HISTOCOMPATIBILITY COMPLEX: A REVIEW
Author(s) -
Preeti Sharma,
Pradeep Kumar,
Rachna Sharma
Publication year - 2017
Publication title -
asian journal of pharmaceutical and clinical research
Language(s) - English
Resource type - Journals
eISSN - 2455-3891
pISSN - 0974-2441
DOI - 10.22159/ajpcr.2017.v10i2.15555
Subject(s) - major histocompatibility complex , immune system , antigen , biology , microbiology and biotechnology , mhc restriction , antigen presentation , cytotoxic t cell , antigen presenting cell , antigen processing , t lymphocyte , t cell , chemistry , immunology , mhc class i , biochemistry , in vitro
One of the important components of the immune system, the major histocompatibility complex (MHC) molecules allow T-lymphocytes to detect cells, such as macrophages, B-lymphocytes, and dendritic cells that ingest infectious microorganisms or the self-cells infected with microorganism. On being engulfed a microorganism, macrophage partially digests it and displays peptide fragments of the microbe on its surface, bound to MHC molecules and the T-lymphocyte recognizes the foreign fragment attached to the MHC molecule and binds to it, lead to stimulation of an immune response. The MHC molecule presents peptides from its own cell (self-peptides) in healthy self-cells to which T-cells do not normally react.Keywords: MHC, B Cells, T Cells, Antigen Processing.