Open AccessCHEMOPROTECTIVE EFFECT OF EDIBLE GASTROPOD, XANCUS PYRUM AND ITS USEFULNESS IN THE AMELIORATION OF CISPLATIN-INDUCED TOXICITY
Author(s) -
Bindhu Jayaprakash,
R. Emilin Renitta
Publication year - 2017
Publication title -
asian journal of pharmaceutical and clinical research
Language(s) - English
Resource type - Journals
eISSN - 2455-3891
pISSN - 0974-2441
DOI - 10.22159/ajpcr.2017.v10i12.21762
Subject(s) - chemoprotective , cisplatin , pharmacology , micronucleus test , chemistry , biochemistry , nephrotoxicity , toxicity , antioxidant , medicine , chemotherapy , organic chemistry
Objective: The main purpose of this study was to evaluate chemoprotective activities of methanolic extracts of an edible gastropod (Xancus pyrum) in cisplatin-induced immunosuppressed mice.Methods: Cisplatin (100 mg/kg, intraperitoneally [IP]) induced immunosuppressed mice were treated with a methanolic extract of X. pyrum (0.5 mg/dose/animal/IP) for a period of 10 days. The effect of the extract on lymphoid organ weight, bone marrow cellularity (BMC), alpha esterase activity, and on enzyme levels such as serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, urea, and creatinine was estimated to identify the chemoprotective activity of X. pyrum.Results: Administration of X. pyrum extract in cisplatin-treated mice, found to enhance the BMC and alpha-esterase positive cells, which were drastically reduced in cisplatin alone treated control animals suggests that cisplatin-induced myelosuppression was reversed or inhibited by X. pyrum extract administration possibly through its chemoprotective activity.Conclusion: Cisplatin and its metabolites can bind to DNA, causing damage that may result in chromosome breaks, micronucleus formation and cell death. Administration of X. pyrum extract in cisplatin-treated mice, found to enhance the BMC and alpha-esterase positive cells, which were drastically reduced in cisplatin alone treated control animals suggests that cisplatin-induced myelosuppression was reversed or inhibited by X. pyrum extract administration possibly through its chemoprotective activity.