Open AccessHEPATOPROTECTIVE EFFECT OF CHENOPODIUM QUINOA SEED AGAINST CCL4-INDUCED LIVER TOXICITY IN SWISS ALBINO MALE MICE
Author(s) -
Sneha Saxena,
Lata Shahani,
Pradeep Bhatnagar
Publication year - 2017
Publication title -
asian journal of pharmaceutical and clinical research
Language(s) - English
Resource type - Journals
eISSN - 2455-3891
pISSN - 0974-2441
DOI - 10.22159/ajpcr.2017.v10i11.20918
Subject(s) - carbon tetrachloride , chenopodium quinoa , alkaline phosphatase , ccl4 , transaminase , glutathione , lipid peroxidation , antioxidant , superoxide dismutase , toxicity , hepatotoxin , alanine transaminase , biology , traditional medicine , chemistry , biochemistry , enzyme , medicine , food science , endocrinology , organic chemistry
Objective: To study the effect of Quinoa seed on carbon tetrachloride (CCL4)-induced liver toxicity in Swiss albino male mice.Methods: Swiss albino male mice were divided into three groups: Group 1 served as control group; Group 2 served as hepatotoxic group (CCl4 treated); and Group 3 served as combination of Quinoa seed powder (20 mg/kg) + CCl4-treated group. The effect of these groups on liver tissue was studied after three different periods of 4, 8, and 12 weeks. Liver marker enzyme level of serum glutamic-oxaloacetic transaminase, serum glutamic-pyruvic transaminase, serum alkaline phosphatase and liver antioxidant enzyme level of lipid peroxidation, superoxide dismutase, and reduced glutathione were measured. Further, histopathological analysis of liver was also conducted.Results: The results showed that the treatment with Quinoa seed powder significantly reduced CCl4-induced elevated serum level of hepatic enzymes and restored the level of liver antioxidant enzymes toward the normal levels, which was also confirmed by histopathological studies.Conclusion: Results of the present study concluded that the Quinoa seed (Chenopodium quinoa) showed hepatoprotective effect against CCl4-induced liver damage in Swiss albino male mice.