Open AccessEXPLOITATION OF HUB PROTEINS AS DRUG TARGETS FOR MYCOBACTERIUM TUBERCULOSIS H37RV
Author(s) -
Asraaa Abdul Jalil
Publication year - 2017
Publication title -
asian journal of pharmaceutical and clinical research
Language(s) - English
Resource type - Journals
eISSN - 2455-3891
pISSN - 0974-2441
DOI - 10.22159/ajpcr.2017.v10i11.20662
Subject(s) - mycobacterium tuberculosis , tuberculosis , coinfection , human immunodeficiency virus (hiv) , drug , computational biology , drug resistance , drug discovery , biology , chemistry , microbiology and biotechnology , bioinformatics , virology , medicine , pharmacology , pathology
Objective: Mycobacterium tuberculosis (TB), a causative agent of TB, increased the resistance to most drugs in use and coinfection with HIV. It needs the new drug(s), the latter should be special candidate targets.Methods: Hub proteins were studied (Rv2198c, Rv2507, and Rv3763) which had very high connected partners. These were modeled to be used for screening chemical databases.Results: The proteins were found to be with increased low-complexity regions especially at the amino ends, they exhibited primary level (layers) of interactions and involved in secondary and more levels of interactions.Conclusions: The proteins with high interacting partners would be good targets as their disruption will disturb the cellular functions. The chosen targets (Rv2198c, Rv2507, and Rv3763) have very high interactions at a different level (layers), they were modeled to be used in survey of chemical databases.