Open AccessAN OVERVIEW OF TRANSDERMAL DELIVERY SYSTEM
Author(s) -
Reshmi Jayaprakash,
Jahnara Hameed,
Anupriya Anupriya
Publication year - 2017
Publication title -
asian journal of pharmaceutical and clinical research
Language(s) - English
Resource type - Journals
eISSN - 2455-3891
pISSN - 0974-2441
DOI - 10.22159/ajpcr.2017.v10i10.19909
Subject(s) - transdermal , stratum corneum , penetration (warfare) , dosage form , bioavailability , systemic circulation , delivery system , pharmacology , drug delivery , drug , biomedical engineering , medicine , penetration rate , chemistry , pathology , engineering , geotechnical engineering , organic chemistry , operations research
Recently, most widely using conventional dosage form such as tablet, capsules, and injections but due to some case we are preferable to choose transdermal drug delivery system (TDDS) because conventional oral dosage form undergo first pass metabolism. In TDDS, skin is the effective medium for the penetration of drug into systemic circulation. This system required very low dose for the effective result or action. One of the major disadvantages of TDDS is penetration rate is very low through the stratum corneum. Nowadays, different types of skin penetration enhancement techniques are used for increasing the penetration. These types of techniques can be also increase the bioavailability. The patients have more preferable to choose this type of drug delivery system because it has more advantages than conventional dosage form. This article is discuses about the anatomy and physiology of skin and its drug penetration capacity, polymers used in transdermal drug delivery and different types of TDDS.