Open AccessHEPATOPROTECTIVE EFFECTS OF POLYHERBAL FORMULATION AGAINST CARBON TETRACHLORIDE-INDUCED HEPATIC INJURY IN ALBINO RATS: A TOXICITY SCREENING APPROACH
Author(s) -
Bhumika Yogi,
Ashutosh Mishra
Publication year - 2016
Publication title -
asian journal of pharmaceutical and clinical research
Language(s) - English
Resource type - Journals
eISSN - 2455-3891
pISSN - 0974-2441
DOI - 10.22159/ajpcr.2017.v10i1.14757
Subject(s) - gymnema sylvestre , carbon tetrachloride , lawsonia inermis , traditional medicine , calotropis procera , pharmacology , chemistry , ccl4 , medicine , organic chemistry
Objective: To investigate the hepatoprotective activity of aqueous methanolic extract of polyherbal formulation and individual extracts of Calotropisprocera, Gymnema sylvestre, and Lawsonia inermis leaves.Methods: The hepatoprotective activity of the formulation and extracts were assessed on the basis of histopathological changes in liver of carbontetrachloride-induced hepatotoxic rats.Results: The result of present studies strongly indicates that the hepatoprotective property of polyherbal formulation as evidenced by less damagedhepatocytes cells.Conclusion: Polyherbal formulation revealed excellent hepatoprotective profile as compared to individual plants due to synergistic effect producedby different phytochemicals present in the formulation.Keywords: Calotropis procera, Gymnema sylvestre, Lawsonia inermis, Carbon tetrachloride.