Open AccessMATRIX METALLOPROTEINASES 2 AND 9 IN AVOCATION OF MULTITUDINAL COMPLICATIONS IN EXPLICITLY TO CARCINOMA: REVIEW
Author(s) -
Stellaa Robertson,
Asha K Rajan,
A Maheshwaran,
B. Senthilnathan,
Sagali Phani Venkata Satya Sai Anuroopa
Publication year - 2016
Publication title -
asian journal of pharmaceutical and clinical research
Language(s) - English
Resource type - Journals
eISSN - 2455-3891
pISSN - 0974-2441
DOI - 10.22159/ajpcr.2017.v10i1.14214
Subject(s) - matrix metalloproteinase , cancer , extracellular matrix , biomarker , immune system , wound healing , matrix (chemical analysis) , homeostasis , medicine , cancer research , metastasis , biology , immunology , microbiology and biotechnology , chemistry , biochemistry , chromatography
Matrix metalloproteinases (MMPs) are a large group of calcium-dependent zinc containing endopeptidases which are mainly concerned with theremodeling of tissue along with degradation of the extracellular matrix. At the present scenario, there is knowledge of about 26 MMPs which are foundto be highly regulated by the growth hormones, cytokines, etc., present within the body. At times of normal homeostasis, their levels within the bodyare low, and their number usually increases at times of pathological conditions. Its generation is known to occur from the pro-inflammatory cells andconnective tissues. They may even lead to the process of apoptosis by its interactions with surface receptors. In the clinical trials sectors, various MMPsalong with their inhibitors are examined to import the properties of being a high biomarker in the cancer diagnosis, antiangiogenic agents, variousother disorders such as chronic allograft nephropathy, diabetic nephropathy, cardiovascular diseases, neuropathic pain, wound healing, angiogenesisprocesses, immune response, corneal ulceration, embryonic development, and nervous system disorders. As a result, enormous number of studies onthis particular enzyme in the marking of cancer and their elevation in the above-mentioned diseases has to be carried out so that it would remain asa useful tool in their diagnosis. The present work is designed to emphasize the concise review of MMPs, in particularly MMP-2 and MMP-9 along withtheir variant roles, keeping in mind, that it would be advantageous for the researchers to bring out more promising results and to intensify diagnosisof various infirmities, especially in cancer.Keywords: Matrix metalloproteinase-2, Matrix metalloproteinase-9, Biomarker, Matrix metalloproteinases, Carcinoma, Extracellular matrix,Malignancy, Gelatinases, Tumor.