Open AccessGENOTOXIC EFFECT OF PESTICIDES ON HUMAN LEUKOCYTE CULTURE: A REVIEW
Author(s) -
DEEPSHIKHA MITRA,
Abilash Vg
Publication year - 2016
Publication title -
asian journal of pharmaceutical and clinical research
Language(s) - English
Resource type - Journals
eISSN - 2455-3891
pISSN - 0974-2441
DOI - 10.22159/ajpcr.2016.v9i5.13080
Subject(s) - genotoxicity , micronucleus test , micronucleus , pesticide , comet assay , biology , sperm , toxicology , dna damage , genetics , chemistry , toxicity , dna , organic chemistry , agronomy
Pesticides have long been in use in the agricultural fields, plantation firms, and also for household purposes. However, there are a considerablenumber of studies which prove the detrimental effects of the pesticides that include biochemical, histopathological, and genetic effects. The aim ofthis article is to present a review on the effects of pesticides on leukocytes which have been analyzed through various assays including chromosomeanalysis, cytokinesis-block micronuclei assay, comet assay, semen, and sperm analysis. The studies have shown organophosphates and carbamates tobe the most potential sources of genotoxicity and the individuals exposed to these groups of pesticides are relatively much more prone to genotoxicity.Further investigation on molecular mechanism by which the pesticides affect the genome of cells needs to be carried out.Keywords: Pesticides, Genotoxicity, Chromosome analysis, Cytokinesis-block micronucleus cytome assay, Semen analysis.