Open AccessAntihyperglycemic and Antioxidant Activity of Nanoemulsion Extracts of <i>M. affine</i> D. Don Leaves in Alloxan-Induced Rat
Author(s) -
Safrida Safrida,
Khairil Khairil,
Fani Fardinita
Publication year - 2020
Publication title -
journal of tropical biodiversity and biotechnology
Language(s) - English
Resource type - Journals
eISSN - 2540-9581
pISSN - 2540-9573
DOI - 10.22146/jtbb.56701
Subject(s) - alloxan , antioxidant , glibenclamide , carboxymethyl cellulose , chemistry , ingredient , ic50 , traditional medicine , dpph , sodium , affine transformation , pharmacology , food science , diabetes mellitus , biochemistry , medicine , in vitro , endocrinology , mathematics , organic chemistry , pure mathematics
This study determined the antihyperglycemic and antioxidant activity of nanoemulsion extracts of M. affine leaves in alloxan-induced rats. This research used 24 male Wistar rats around three months old which grouped as normal (untreated), negative control (treated with carboxymethyl cellulose sodium/Na-CMC,), positive control (treated with glibenclamide), and various concentration (30, 60, and 90%) of nanoemulsion extract of M. affine leaves groups. The extract of M. affine leaves had an antioxidant activity with IC50 5.30 ppm, categorized as a very strong antioxidant. Furthermore, the administration of this extract decreased glucose levels in antihyperglycemic rats. We concluded that M. affine leaves extract potential as antioxidants and be developed as an ingredient for diabetic drugs.