Open AccessMyrmecodia platytyrea Methanol Tuber Extract Ameliorates Hyperglycemia In STZ-Induced Diabetic Sprague-Dawley Male Rats
Author(s) -
Mizaton Hazizul Hasan,
Hasbullani Zakaria,
Aminah Aminah,
Thellie Ponto,
Aishah Adam
Publication year - 2021
Publication title -
indonesian journal of pharmacy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.153
H-Index - 6
eISSN - 2338-9486
pISSN - 2338-9427
DOI - 10.22146/ijp.880
Subject(s) - medicine , streptozotocin , diabetes mellitus , metformin , kidney , potency , endocrinology , pancreas , traditional medicine , chemistry , biochemistry , in vitro
Type 2 diabetes mellitus (T2DM) is one of the main non-communicable chronic diseases that has many complications that compromise the quality of life. Hence, the need to find alternatives to replace the current therapy or as an adjuvant. Tubers of Myrmecodia platytytrea (Rubiaceae) has been used traditionally as an alternative therapy for the management of cancer and other inflammatory-related disorders. The aim of this study was to investigate the potency of M. platytytrea methanolic tuber extract (MPMTE) as an antihyperglycemic agent, in vivo. :The streptozotocin (STZ)-induced diabetic rats were treated orally with MPMTE (100, 200 and 400 mg/kg) and metformin (positive control, 100 mg/kg) daily for 14 days. Blood glucose level and other biochemistry analysis were conducted including histological examination on liver, kidney and pancreas. The STZ-induced diabetic rats treated with MPMTE (200 and 400 mg/kg) had significant decreased (p<0.05) in fasting blood glucose, total cholesterol, triglycerides and low-density lipoprotein (LDL) with no significant changes in high-density lipoprotein (HDL) compared to STZ-induced untreated diabetic rats. Liver, kidney and pancreas were devoid of any damage caused by STZ. MPMTE had strong antihyperglycaemic activity and was protective against any STZ-induced organ damage. Thus, MPMTE can be further developed into an adjuvant therapy for diabetic patients.