Open AccessSYNTHESIS OF SAFRYL KETONE FROM SAFROLE
Author(s) -
Hanoch Julianus Sohilait,
Hardjono Sastrohamidjojo,
Sabirin Matsjeh,
J. Stuart Grossert
Publication year - 2010
Publication title -
indonesian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.273
H-Index - 14
eISSN - 2460-1578
pISSN - 1411-9420
DOI - 10.22146/ijc.21874
Subject(s) - safrole , chemistry , ketone , alcohol , fourier transform infrared spectroscopy , proton nmr , allyl alcohol , organic chemistry , nuclear magnetic resonance spectroscopy , proton magnetic resonance , catalysis , nuclear magnetic resonance , chromatography , physics , quantum mechanics
Synthesis of safryl ketone from safrole has been achieved through conversion of allyl group to secondary alcohol, followed by oxidation with PCC-Al2O3. The oxymecuration-demercuration reaction of safrole with HgSO4-NaBH4 yields safryl alcohol (66.38%) and the oxidation of safryl alcohol with PCC-Al2O3 yields safryl ketone (62.92%). The structure elucidation of these products was conducted using Fourier Transformed Infra Red Spectroscopy (FTIR), Proton-Nuclear Magnetic Resonance (1H-NMR) and Mass Spectroscopy (MS). Keywords: safryl ketone, safrole